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An opioid analgesic with significant painkilling properties, tapentadol is used to treat moderate to severe pain. In the United States, it was authorized for medicinal use in 2008 after initially being created by the German pharmaceutical company Grnenthal.

Due to its potential for abuse and dependence, tapentadol is listed as a Schedule II restricted substance in the US. Tapentadol must only be used as directed and must not be given to anybody else.

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By interacting with opioid receptors in the brain and spinal cord, tapentadol lessens the sense of pain. Additionally, it prevents norepinephrine from being reabsorbed, which helps it have an analgesic effect. Norepinephrine is a neurotransmitter that plays a role in the body's pain response.

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