The Week 5schedule features a pair of high-profile playoff rematches from last season, and a potential thriller on the West Coast on Sunday afternoon.The Rams and Seahawks meet on Thursday Night Football in a rematch of last years NFC first-round matchup. Los Angeles is a 1.5-point favorite on the road, and it is Matthew Staffords chance to get his first victory at Seattle as a starting quarterback.The AFC championship rematch between the Chiefs and Bills is huge on Sunday Night Football, which has produced some of the best games of the season. That trend continues in a battle of two teams hoping to be the top seed in the AFC.Keep an eye on the 4:05 p.m. ET matchup between the Browns and Chargers, too. Both teams are trying to stay in tough division races, and the quarterback matchup between Justin Herbert and Baker Mayfield should produce a thriller.Each week, Sporting News will pick games straight up. Here is a look at our season totals:Week 4: 12-4Season total: 41-23With that in mind, Mike Singletary Jersey below are our picks and predictions for Week 4:POWER RANKINGS: NFL picks, predictions for Week 5Los Angeles Rams (-1.5) at Seattle SeahawksThursday, 8:20 p.m., FOX/NFL NetworkThe NFC West grinder continues. The Rams took their first lo s, and the Seahawks are coming off a big victory. Sean McVay is 6-3 head-to-head against Pete Carroll, and Taylor Gabriel Jersey that includes a 3-2 record at Lumen Field. This will be a tight game, and Seattle starts the week off with a surprise upset.Pick: Seahawks 27, Rams 24Result: Rams 26, Seahawks 17New York Jets at Atlanta Falcons (-2.5)Sunday, 9:30 a.m., NFL NetworkThe Jets got on the board last week, and Atlanta allows the most points in the NFL at 32 points per game. New York still commits too many turnovers, and without a running game that's going to be tough to win on the road.Pick: Falcons 30, Jets 20Green Bay Packers (-3) at Cincinnati BengalsSunday, 1 p.m., FOXThe Packers have lost their last two trips to Cincinnati. In 2005, a fan stole the ball from Brett Favre. In 2013, Terence Newman scored on a fumble return for a TD. That's our way of saying strange things could happen if the Packers start slow. Joe Mixon (ankle) and Jaire Alexander (shoulder) are key injuries in what should be another close encounter for the Packers.Pick: Packers 28, Bengals 25 Detroit Lions at Minnesota Vikings (-10)Sunday, 1 p.m., FOXWe tried the Lions for a NFC North upset last week. That didn't work. It's not going to happen in Minnesota either. Both teams struggle against the run, so Kirk Cousins and Jared Goff should enjoy nice games. The Vikings need to get Dalvin Cook on track if they want to keep up in the Eddie Goldman Jersey NFC North.Pick: Vikings 26, Lions 22Denver Broncos (-1.5) at Pittsburgh SteelersSunday, 1 p.m., FOXTeddy Bridgewater (concu sion) might mi s this game, and that impacts our pick. The Steelers are a brutal watch at times on offense, but the defense should be able to force a few turnovers from Drew Luck. Pittsburgh guts out an ugly win with a late drive from Ben Roethlisberger, but it isn't pretty.Pick: Steelers 23, Broncos 21Miami Dolphins at Tampa Bay Buccaneers (-9.5)Sunday, 1 p.m., CBSThe Dolphins are in an early-season slide. Miami has yet to have a game with at least 200 yards pa sing, and that's bad news against Tom Brady and a versatile Buccaneers' offense. Miami had some memorables upsets involving Brady when he was in New England. This wont be one of those moments.Pick: Buccaneers 30, Dolphins 19 New Orleans Saints (-2.5) at Washington Football TeamSunday, 1 p.m., CBSThe Saints have been inconsistent through four weeks, and the pa s defense was a me s against the Giants in Week 5. Taylor Heinicke has played well enough in three starts to keep the ball moving at home, and the defense will force a few interceptions.Pick: Washington 24, Saints 23Philadelphia Eagles at Carolina Panthers (-3)Sunday, 1 p.m., FOXThe Eagles are another NFC East underdog who can pull an upset on the road. Philadelphia has i sues against the run, but will the Panthers stick with it long enough? Jalen Hurts spreads out the Panthers defense and avoids the big turnover, and Miles Sanders scores the game-winning James Daniels Jersey TD in the fourth quarter.Pick: Eagles 28, Panthers 21Tenne see Titans (-4.5) at Jacksonville JaguarsSunday, 1 p.m., CBSThe Jaguars are still looking for that first victory under first-year coach Urban Meyer, and Tenne see proved vulnerable without starting receivers A.J. Brown and Julio Jones in Week 5. The bad news for Meyer? Mike Vrabel will feed Derrick Henry early, and the Jacksonville pa s defense will be exploited once more.Pick: Titans 30, Jaguars 26 New England Patriots (-8.5) at Houston TexansSunday, 1 p.m., CBSThe Pats lost the "Brady Bowl," but Mac Jones poise as a rookie quarterback continues to be an early-season surprise. Houston has scored a total of nine points in their last two lo ses, and New England should be able to grind out a victory on the road. The spread is still too high.Pick: Patriots 20, Texans 14Chicago Bears at Las Vegas Raiders (-5.5)Sunday, 4:05 p.m., CBSFor all the hand-wringing about Matt Nagy, the Bears are 2-2 and have a chance to take a winning record into a home game against the Packers in Week 6. The Raiders are coming off a short week. Despite Chicagos quarterback questions, the recipe for an off-the-wall-thriller is there.Pick: Bears 26, Raiders 24Cleveland Browns at Los Angeles Chargers (-2.5)Sunday, 4:05 p.m., CBSBaker Mayfield did not play well in Week 4 at Minnesota, and the Browns won. Hint: Its not always about Mayfield. The Browns have the top rushing offense in the NFL, and the defense flexed the last two weeks. The Chargers will offer a preview of whats to come in the playoffs, but championship-caliber teams win on the road. Mayfield bounces back in another clutch road victory.Pick: Browns 31, Chargers 24 New YorkGiants at Dallas Cowboys (-7)Sunday, 4:25 p.m., FOXThe Cowboys have the second-best running game in the NFL, Sherrick McManis Jersey and the Tony Pollard-Ezekiel Elliott combination has helped Dak Prescott, who was lost for the season in this game in 2020. The Cowboys hype is coming, and it builds with another NFC East victory at home.Pick: Cowboys 28, Giants 19San Francisco 49ers at Arizona Cardinals (-5.5)Sunday, 4:25 p.m., FOXIts tempting to take the 49ers if Trey Lance starts, especially with the buil