Fragment-Based Drug Discovery Market Segmentation and Future Scope with Top Players, Regional Trends, and Size Insights

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According to Straits Research, the global fragment-based drug discovery market size was valued at USD 868.42 million in 2023. It is projected to reach from USD 954.32 million in 2024 to USD 2,313.43 million by 2032, growing at a CAGR of 11.5% during the forecast period (2024–2032).

Straits Research is pleased to present the latest insights on the Fragment-Based Drug Discovery Market, which is witnessing significant growth across the global healthcare landscape. The global market, valued at USD 868.42 million in 2023, is projected to grow from USD 954.32 million in 2025 to USD 2,313.43 million by 2032, expanding at a compound annual growth rate (CAGR) of 11.5% during the forecast period (2025–2032). The report provides a comprehensive overview of the current trends, growth drivers, and future opportunities in this emerging market.

Market Definition

Fragment-Based Drug Discovery (FBDD) is a technique used in drug development, where small, low-molecular-weight chemical fragments are screened and optimized to bind to biological targets associated with diseases. This approach enables the identification of lead compounds that can be developed into potent therapeutics. With the increasing focus on precision medicine and novel therapies for complex diseases, FBDD has become an essential tool for pharmaceutical and biotechnology companies.

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Latest 3 Trends in Fragment-Based Drug Discovery

  1. Integration of Artificial Intelligence and Machine Learning: Artificial intelligence (AI) and machine learning (ML) technologies are being increasingly utilized in fragment-based drug discovery. These technologies allow for the efficient analysis of large datasets, improving the prediction of binding affinities and optimizing the selection of fragments for lead discovery.

  2. Emergence of Novel Biophysical Techniques: The use of advanced biophysical techniques, such as NMR SpectroscopyX-ray Crystallography, and Mass Spectrometry, is enhancing the precision and speed of fragment screening. These innovations are driving the adoption of fragment-based drug discovery by providing deeper insights into molecular interactions and accelerating the identification of promising drug candidates.

  3. Focus on Oncology and CNS Disorders: There is a growing emphasis on using fragment-based drug discovery for oncology and central nervous system (CNS) disorders. With increasing incidences of cancer and neurological diseases, the ability to develop specific and potent drugs for these conditions is more crucial than ever. FBDD provides a unique advantage in targeting complex proteins and developing drugs with improved efficacy and reduced side effects.

3 Growth Factors Driving the Market

  1. Increased Demand for Targeted Therapies: The shift towards personalized medicine and the growing demand for targeted therapies have boosted the adoption of FBDD. By focusing on specific molecular targets, FBDD provides a means to design drugs that are more effective with fewer side effects.

  2. Rising Incidences of Chronic Diseases: The global rise in chronic diseases such as cancer, metabolic disorders, and cardiovascular diseases is driving the need for new therapeutic solutions. FBDD offers a promising approach to discover novel drugs to treat these diseases by targeting proteins involved in the disease processes.

  3. Advancements in Drug Discovery Technologies: Continued advancements in fragment screening and optimization techniques, such as biophysical and non-biophysical methods, have improved the efficiency and effectiveness of drug discovery. The integration of AI and ML tools is further accelerating the identification of promising drug candidates, enabling quicker and more cost-effective drug development.

3 Key Market Opportunities

  1. Expanding Applications in Drug Development: The increasing use of FBDD for various therapeutic areas such as oncologyCNS disorders, and infectious diseases presents numerous growth opportunities. As more pharmaceutical companies adopt FBDD, there is potential for rapid expansion in these areas.

  2. Collaborations and Strategic Partnerships: Companies in the fragment-based drug discovery market are forming collaborations with academic institutions, contract research organizations (CROs), and other stakeholders. These strategic alliances help drive innovation, provide access to advanced technologies, and expand market presence.

  3. Emerging Markets in Asia-Pacific: With Asia-Pacific being the fastest-growing region in the FBDD market, there are substantial growth opportunities in this region. The increasing healthcare investments and growing pharmaceutical industries in countries such as China, India, and Japan make Asia-Pacific an attractive region for market players to explore.

Market Segmentation

The Fragment-Based Drug Discovery Market is segmented as follows:

By Service Components:

  1. Fragment Screening
    • Biophysical Techniques
      • NMR Spectroscopy
      • DSF Assay
      • Fluorescence Polarization (FP)
      • Isothermal Titration Calorimetry (ITC)
      • X-ray Crystallography
      • Surface Plasmon Resonance
      • Mass Spectrometry
      • Capillary Electrophoresis
      • Other Biophysical Techniques
      • Non-biophysical Techniques
    • Non-Biophysical Techniques
  2. Fragment Optimization

By End-User:

  1. Biopharmaceutical Companies
  2. CROs
  3. Academic and Research Institutions

By Applications:

  1. Oncology
  2. Central Nervous System (CNS) Disorders
  3. Infectious Diseases
  4. Cardiovascular Diseases
  5. Metabolic Disorders
  6. Inflammation and Autoimmune Diseases

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Key Players in the Fragment-Based Drug Discovery Market

The market is dominated by several key players, including:

  1. Pfizer Inc.
  2. Novartis AG
  3. Johnson & Johnson
  4. Alveus Pharmaceuticals Pvt. Ltd.
  5. Astex Pharmaceuticals
  6. Charles River Laboratories International, Inc.
  7. Beactica AB
  8. Emerald BioStructures, Inc.
  9. Crown Bioscience, Inc.
  10. Evotec AG
  11. Proteros Fragments GmbH
  12. Kinetic Discovery Limited
  13. Sprint Bioscience
  14. Sygnature Discovery
  15. Structure Based Design, Inc.

Regional Insights

  • Dominated Region: North America
    North America holds the largest market share in fragment-based drug discovery, attributed to the presence of major pharmaceutical companies and research institutions in the U.S. and Canada. The increasing investment in drug discovery and development and a strong emphasis on precision medicine contribute to the region's dominance.

  • Fastest Growing Region: Asia Pacific
    The Asia-Pacific region is expected to witness the fastest growth in the market. Countries like China, Japan, and India are experiencing rapid advancements in healthcare infrastructure and pharmaceutical R&D, positioning Asia Pacific as a key player in the global market.

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About Straits Research

Straits Research is a leading global market research and consulting firm providing comprehensive insights into a wide array of industries. We specialize in delivering data-driven market intelligence reports, offering actionable insights, strategic guidance, and market forecasts. Our deep understanding of industry trends and dynamics helps businesses make informed decisions to foster growth and success.

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