Though the company has voluntarily withdrawn the controversial drug from the market, it continues to believe in the safety and efficacy of the drug. The decision to pull out Endo Pharmaceuticals' drug by the FDA came after a review of the available post-marketing data. Supposedly, there has been a marked shift in the abuse of Opana ER 30mg from nasal to injection due to the reformulation of the product.

It was suggested that the drug that was reformulated in 2012 and aimed to be labeled as an abuse-deterrent opioid was found to significantly increase the outbreak of HIV and hepatitis C among intravenous users. However, the FDA did not deem Opana ER 30mg to be an abuse-deterrent opioid because it failed to meet its standard.

The drug was first approved in 2006 to manage moderate-to-severe pain as an opioid analgesic that worked over an extended period. In 2015, Endo Pharmaceuticals sold $158 million worth of Opana ER 30mg.
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